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Myosin II regulates complex cellular arrangement and epithelial architecture in Drosophila.

Abstract:

Remodeling epithelia is a primary driver of morphogenesis. Here, we report a central role of myosin II in regulating several aspects of complex epithelial architecture in the Drosophila eye imaginal disc. The epithelial indentation of the morphogenetic furrow is established from a pattern of myosin II activation defined by the developmental signals Hedgehog and Decapentaplegic. More generally, patterned myosin activation can control diverse three-dimensional epithelial sculpting. We have deve...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Developmental cell
Volume:
13
Issue:
5
Pages:
717-729
Publication date:
2007-11-01
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
Source identifiers:
356055
Language:
English
Keywords:
Pubs id:
pubs:356055
UUID:
uuid:ddfc6864-f13a-4bbe-8c66-b0901dcaa429
Local pid:
pubs:356055
Deposit date:
2013-11-16

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