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A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development

Abstract:

Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC/C) in mitosis, and facilitate degradation of mitotic APC/C substrates. The malaria parasite, Plasmodium, is a haploid organism which, during its life-cycle undergoes two stages of mitosis; one associated with asexual multiplication and the other ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.ppat.1002554

Authors


Guttery, DS More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Straschil, U More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
8
Issue:
2
Pages:
e1002554
Publication date:
2012-02-23
Acceptance date:
2012-01-12
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:ddd7805d-6346-4493-b80d-5e6b71ae6873
Source identifiers:
334152
Local pid:
pubs:334152

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