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Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids.

Abstract:

BACKGROUND: The debate as to whether asthma is a single or heterogeneous disease remains unresolved although pathological studies, mostly using fibreoptic bronchoscopy on small numbers of subjects, have emphasised the similarities between different clinical phenotypes. METHODS: Lower airway inflammation was assessed non-invasively using induced sputum in 34 normal controls and 259 adults with symptomatic asthma receiving treatment at steps 1-3 of the British Thoracic Society (BTS) guidelines....

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Publisher copy:
10.1136/thorax.57.10.875

Authors


Brightling, CE More by this author
Woltmann, G More by this author
Wardlaw, AJ More by this author
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Journal:
Thorax
Volume:
57
Issue:
10
Pages:
875-879
Publication date:
2002-10-05
DOI:
EISSN:
1468-3296
ISSN:
0040-6376
URN:
uuid:ddd616cc-e6c6-41e7-8d3b-69bad4a76e0c
Source identifiers:
435353
Local pid:
pubs:435353

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