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TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP.

Abstract:

Two-pore channels (TPCs or TPCNs) are novel members of the large superfamily of voltage-gated cation channels with slightly higher sequence homology to the pore-forming subunits of voltage-gated Ca(2+) and Na(+) channels than most other members. Recent studies demonstrate that TPCs locate to endosomes and lysosomes and form Ca(2+) release channels that respond to activation by the Ca(2+) mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). With multiple endolysosomal t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Journal:
FEBS letters
Volume:
584
Issue:
10
Pages:
1966-1974
Publication date:
2010-05-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:ddc54658-ff47-4af3-a0e9-9d0bdc9d2266
Source identifiers:
106421
Local pid:
pubs:106421

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