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Neural Plasticity in Human Brain Connectivity: The Effects of Long Term Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease

Abstract:

Background: Positive clinical outcomes are now well established for deep brain stimulation, but little is known about the effects of long-term deep brain stimulation on brain structural and functional connectivity. Here, we used the rare opportunity to acquire pre- and postoperative diffusion tensor imaging in a patient undergoing deep brain stimulation in bilateral subthalamic nuclei for Parkinson’s Disease. This allowed us to analyse the differences in structural connect...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0086496

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Funding agency for:
van Hartevelt, T
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Funding agency for:
Cabral, J
Grant:
DYSTRUCTURE (n. 295129)
More from this funder
Funding agency for:
Cabral, J
Grant:
DYSTRUCTURE (n. 295129)
More from this funder
Funding agency for:
Cabral, J
Grant:
DYSTRUCTURE (n. 295129)
More from this funder
Funding agency for:
Cabral, J
Grant:
DYSTRUCTURE (n. 295129)
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
9
Issue:
1
Pages:
e86496
Publication date:
2014-01-22
DOI:
Source identifiers:
447057
Pubs id:
pubs:447057
UUID:
uuid:ddbbd93c-bbe2-4378-8436-20a0a4f7b95a
Local pid:
pubs:447057
Deposit date:
2014-01-30

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