Interference of angiotensin-converting enzyme inhibition with vasoactive peptides in the coronary circulation of dogs.

Journal article

The coronary effects of angiotensin-converting enzyme (ACE) inhibitors and their mechanisms of action are not well understood. Because these drugs may interfere with hormone systems other than the reninangiotensin system (RAS), we studied modulation of the coronary effects of neurotensin, neuropeptide Y (NPY), and endothelin-1 (ET-1) by pretreatment with captopril in anesthetized, open-chest dogs. The left anterior descending coronary artery (LAD) was cannulated and perfused at a pressure equ...

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Authors: Bauer, B; Neubauer, S; Spindler, M; Dürr, R; Becker, H

• Journal: Journal of cardiovascular pharmacology
• Volume: 25
• Issue: 5
• Pages: 756-762
• Publication date: 1995-05-01
• DOI: 10.1097/00005344-199505000-00011
• EISSN: 1533-4023
• ISSN: 0160-2446
• Language: English
• Keywords: Analysis of Variance; Female; Neuropeptide Y; Coronary Circulation; Neurotensin; Endothelins; Male; Infusions, Intra-Arterial; Rheology; Dogs; Drug Interactions; Injections, Intra-Arterial; Captopril; Dose-Response Relationship, Drug; Animals; Coronary Vessels