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The antiviral RNAi response in vector and non-vector cells against orthobunyaviruses.

Abstract:

Background

Vector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and Piwi-interacting RNA (piRNA) pathways, but direct antiviral activity by these host responses in mosquito cells has only been demonstrated against a limited number of positive-strand RNA arboviruses. For bunyaviruses in general, the r...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pntd.0005272

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
McFarlane, M More by this author
Blomström, AL More by this author
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Contributors

Role:
Editor
Swedish Research Council More from this funder
European Research Area More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
11
Issue:
1
Pages:
e0005272
Publication date:
2017-01-05
Acceptance date:
2016-12-20
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Pubs id:
pubs:681867
URN:
uri:dd97c503-e51b-46ca-8a9a-4dc7ead7497f
UUID:
uuid:dd97c503-e51b-46ca-8a9a-4dc7ead7497f
Local pid:
pubs:681867

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