High-frequency stimulation of the subthalamic nucleus inhibits the firing of juxtacellular labelled 5-HT-containing neurones.

Journal article

High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is an established neurosurgical therapy for movement disability in advanced Parkinson's disease (PD), but some patients experience psychiatric side-effects like depression. In a previous electrophysiological study, we observed that HFS of the STN inhibited a population of neurones in the rat dorsal raphe nucleus (DRN), with firing properties characteristic of 5-HT neurones. The present study extended these findings to a second ...

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Authors: Hartung, H; Tan, S; Steinbusch, H; Temel, Y; Sharp, T

• Publication status: Published
• Journal: Neuroscience
• Volume: 186
• Pages: 135-145
• Publication date: 2011-07-01
• DOI: 10.1016/j.neuroscience.2011.04.004
• EISSN: 1873-7544
• ISSN: 0306-4522
• Language: English
• Keywords: Rats, Sprague-Dawley; Action Potentials; Male; Rats; Mesencephalon; Electric Stimulation Therapy; Serotonin; Raphe Nuclei; Neural Inhibition; Animals; Subthalamic Nucleus