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High-frequency stimulation of the subthalamic nucleus inhibits the firing of juxtacellular labelled 5-HT-containing neurones.

Abstract:

High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is an established neurosurgical therapy for movement disability in advanced Parkinson's disease (PD), but some patients experience psychiatric side-effects like depression. In a previous electrophysiological study, we observed that HFS of the STN inhibited a population of neurones in the rat dorsal raphe nucleus (DRN), with firing properties characteristic of 5-HT neurones. The present study extended these findings to a second ...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Neuroscience
Volume:
186
Pages:
135-145
Publication date:
2011-07-01
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
Source identifiers:
185263
Language:
English
Keywords:
Pubs id:
pubs:185263
UUID:
uuid:dd93ef2d-e827-4ea6-aa8d-cd6bbfe50bc1
Local pid:
pubs:185263
Deposit date:
2012-12-19

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