Journal article icon

Journal article

VanB-type Enterococcus faecium clinical isolate successively inducibly resistant to, dependent on, and constitutively resistant to vancomycin.

Abstract:

Three Enterococcus faecium strains isolated successively from the same patient, vancomycin-resistant strain BM4659, vancomycin-dependent strain BM4660, and vancomycin-revertant strain BM4661, were indistinguishable by pulsed-field gel electrophoresis and harbored plasmid pIP846, which confers VanB-type resistance. The vancomycin dependence of strain BM4660 was due to mutation P(175)L, which suppressed the activity of the host Ddl D-Ala:D-Ala ligase. Reversion to resistance in strain BM4661 wa...

Expand abstract

Actions


Access Document


Publisher copy:
10.1128/aac.00034-09

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Depardieu, F More by this author
Godreuil, S More by this author
Courvalin, P More by this author
Journal:
Antimicrobial agents and chemotherapy
Volume:
53
Issue:
5
Pages:
1974-1982
Publication date:
2009-05-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:dd92b2f4-037b-4a39-bf51-7fc1c494e6f4
Source identifiers:
386892
Local pid:
pubs:386892

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP