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Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding.

Abstract:

S-1153 (AG1549) is perhaps the most promising non-nucleoside inhibitor of HIV-1 reverse transcriptase currently under development as a potential anti-AIDS drug, because it has a favorable profile of resilience to many drug resistance mutations. We have determined the crystal structure of S-1153 in a complex with HIV-1 reverse transcriptase. The complex possesses some novel features, including an extensive network of hydrogen bonds involving the main chain of residues 101, 103, and 236 of the ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.275.19.14316

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Journal:
The Journal of biological chemistry
Volume:
275
Issue:
19
Pages:
14316-14320
Publication date:
2000-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:dd865acb-c7b9-4ac4-9341-9721099e4df4
Source identifiers:
12387
Local pid:
pubs:12387

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