- Abstract:
-
Hippocampal CA1 pyramidal cells, which receive γ-aminobutyric acid (GABA)ergic input from at least 18 types of presynaptic neuron, express 14 subunits of the pentameric GABA(A) receptor. The relative contribution of any subunit to synaptic and extrasynaptic receptors influences the dynamics of GABA and drug actions. Synaptic receptors mediate phasic GABA-evoked conductance and extrasynaptic receptors contribute to a tonic conductance. We used freeze-fracture replica-immunogold labelling, a se...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1460-9568.2010.07473.x
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- Journal:
- The European journal of neuroscience
- Volume:
- 32
- Issue:
- 11
- Pages:
- 1868-1888
- Publication date:
- 2010-12-05
- DOI:
- EISSN:
-
1460-9568
- ISSN:
-
0953-816X
- URN:
-
uuid:dd82c3bc-37ea-42f2-935e-1d8b3315b8d6
- Source identifiers:
-
329274
- Local pid:
- pubs:329274
- Copyright date:
- 2010
Journal article
Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling.
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