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Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling.

Abstract:

Hippocampal CA1 pyramidal cells, which receive γ-aminobutyric acid (GABA)ergic input from at least 18 types of presynaptic neuron, express 14 subunits of the pentameric GABA(A) receptor. The relative contribution of any subunit to synaptic and extrasynaptic receptors influences the dynamics of GABA and drug actions. Synaptic receptors mediate phasic GABA-evoked conductance and extrasynaptic receptors contribute to a tonic conductance. We used freeze-fracture replica-immunogold labelling, a se...

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Publication status:
Published

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Journal:
The European journal of neuroscience
Volume:
32
Issue:
11
Pages:
1868-1888
Publication date:
2010-12-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:dd82c3bc-37ea-42f2-935e-1d8b3315b8d6
Source identifiers:
329274
Local pid:
pubs:329274

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