Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.

Journal article

OBJECTIVE: To determine the pharmacokinetic properties of dihydroartemisinin (DHA) following oral artesunate treatment in women with recrudescent multi-drug resistant falciparum malaria, in the second and third trimesters of pregnancy. METHODS: Serial plasma concentrations of artesunate and DHA were measured in 24 women after the final dose of a 3 day treatment with artesunate (4 mg kg(-1) day(-1)) and atovaquone (20 mg kg(-1) day(-1)) plus proguanil (8 mg kg(-1) day(-1)), daily. Conventiona...

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Authors: Mcgready, R; Stepniewska, K; Ward, SA; Cho, T; Gilveray, G

• Publication status: Published
• Journal: European journal of clinical pharmacology
• Volume: 62
• Issue: 5
• Pages: 367-371
• Publication date: 2006-05-01
• DOI: 10.1007/s00228-006-0118-y
• EISSN: 1432-1041
• ISSN: 0031-6970
• Language: English
• Keywords: Analysis of Variance; Female; Pregnancy Complications, Parasitic; Adult; Malaria, Falciparum; Humans; Pregnancy Trimester, Third; Half-Life; Adolescent; Pregnancy; Drug Therapy, Combination; Artemisinins; Proguanil; Thailand; Antimalarials; Atovaquone; Pregnancy Outcome; Drug Resistance, Multiple; Pregnancy Trimester, Second; Acute Disease; Drug Combinations; Sesquiterpenes