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Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.

Abstract:

OBJECTIVE: To determine the pharmacokinetic properties of dihydroartemisinin (DHA) following oral artesunate treatment in women with recrudescent multi-drug resistant falciparum malaria, in the second and third trimesters of pregnancy. METHODS: Serial plasma concentrations of artesunate and DHA were measured in 24 women after the final dose of a 3 day treatment with artesunate (4 mg kg(-1) day(-1)) and atovaquone (20 mg kg(-1) day(-1)) plus proguanil (8 mg kg(-1) day(-1)), daily. Conventiona...

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Publication status:
Published

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Publisher copy:
10.1007/s00228-006-0118-y

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Journal:
European journal of clinical pharmacology
Volume:
62
Issue:
5
Pages:
367-371
Publication date:
2006-05-01
DOI:
EISSN:
1432-1041
ISSN:
0031-6970
Source identifiers:
24968

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