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Characterization of a panel of novel anti-p21Waf1/Cip1 monoclonal antibodies and immunochemical analysis of p21Waf1/Cip1 expression in normal human tissues.

Abstract:

As a universal inhibitor of cyclin-dependent kinases and one of the target genes of the tumor suppresser p53, p21Waf1/Cip1 can act as a tumor suppresser through its ability to control cell cycle progression. To study the function of p21Waf1/Cip1 protein and to investigate its tissue distribution, a panel of anti-p21Waf1/Cip1 monoclonal antibodies was generated. These anti-p21Waf1/Cip1 monoclonal antibodies were initially raised against a GST-p21Waf1/Cip1 fusion protein produced in bacteria. D...

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Publication status:
Published

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Authors


Fredersdorf, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Journal:
The American journal of pathology
Volume:
148
Issue:
3
Pages:
825-835
Publication date:
1996-03-05
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:dd67251f-343d-45bc-9d03-7e7c665a14ac
Source identifiers:
84025
Local pid:
pubs:84025

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