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Gyrification of Broca's region is anomalously lateralized at onset of schizophrenia in adolescence and regresses at 2 year follow-up.

Abstract:

Gyrification of the human cerebral cortex starts in the foetus and progresses in early infancy; the pattern of folding in later life provides a lead to early developmental aberration. By studying gyrification at illness onset in adolescence we hoped to clarify the pathophysiology of schizophrenia. Here we find 1) an area of hypergyria includes Broca's area and extends into the Sylvian fissure to encroach on the anterior insula in the left hemisphere, and 2) an area of hypogyria in the superio...

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Publication status:
Published

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Authors


Palaniyappan, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Liddle, PF More by this author
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Journal:
Schizophrenia research
Volume:
147
Issue:
1
Pages:
39-45
Publication date:
2013-06-05
DOI:
EISSN:
1573-2509
ISSN:
0920-9964
URN:
uuid:dd638f7d-1c63-4558-b871-62da101fbcce
Source identifiers:
396232
Local pid:
pubs:396232

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