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Journal article

The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.

Abstract:

BACKGROUND: Signalling via the Notch receptor is a key regulator of many developmental processes. The differential responsiveness of Notch-expressing cells to the ligands Delta and Serrate is controlled by Fringe, itself essential for normal patterning in Drosophila and vertebrates. The mechanism of Fringe action, however, is not known. The protein has an amino-terminal hydrophobic stretch resembling a cleaved signal peptide, which has led to the widespread assumption that it is a secreted si...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Current biology : CB
Volume:
10
Issue:
14
Pages:
813-820
Publication date:
2000-07-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:dd4da598-06a5-4708-8d2e-324f6a40cb15
Source identifiers:
356098
Local pid:
pubs:356098

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