The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.

Journal article

BACKGROUND: Signalling via the Notch receptor is a key regulator of many developmental processes. The differential responsiveness of Notch-expressing cells to the ligands Delta and Serrate is controlled by Fringe, itself essential for normal patterning in Drosophila and vertebrates. The mechanism of Fringe action, however, is not known. The protein has an amino-terminal hydrophobic stretch resembling a cleaved signal peptide, which has led to the widespread assumption that it is a secreted si...

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Authors: Munro, S; Freeman, M

• Publication status: Published
• Journal: Current biology : CB
• Volume: 10
• Issue: 14
• Pages: 813-820
• Publication date: 2000-07-01
• DOI: 10.1016/s0960-9822(00)00578-9
• EISSN: 1879-0445
• ISSN: 0960-9822
• Language: English
• Keywords: Protein Binding; Receptors, Notch; Golgi Apparatus; Amino Acid Sequence; Sequence Homology, Amino Acid; Drosophila Proteins; Signal Transduction; Eye; Amino Acid Motifs; Mutagenesis, Site-Directed; Drosophila; Wing; Protein Sorting Signals; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Glycosyltransferases; Uridine Diphosphate; Membrane Proteins; Recombinant Proteins; Insect Proteins; Animals