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Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions.

Abstract:

G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-stranded DNA. Recently, a biochemically distinct family of DNA repair enzymes has been identified, which excises both uracil and thymine, but only from mispairs with guanine. Crystal structures of the mismatch-specific uracil DNA-glycosylase (MUG) f...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Journal:
Cell
Volume:
92
Issue:
1
Pages:
117-129
Publication date:
1998-01-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:dd4ca3dc-ddd7-439b-8dab-2a9229729443
Source identifiers:
400272
Local pid:
pubs:400272

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