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Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex

Abstract:

Magnetic resonance spectroscopy (MRS) allows measurement of neurotransmitter concentrations within a region of interest in the brain. Inter-individual variation in MRS-measured GABA levels have been related to variation in task performance in a number of regions. However, it is not clear how MRS-assessed measures of GABA relate to cortical excitability or GABAergic synaptic activity. We therefore performed two studies investigating the relationship between neurotransmitter levels as assessed ...

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Authors


Bestmann, S More by this author
Constantinescu, AO More by this author
Moreno Moreno, L More by this author
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Journal:
Journal of Physiology
Volume:
589
Issue:
23
Pages:
5845-5855
Publication date:
2011-12-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:dd4b2016-d0b7-4dfa-9fb2-28adfb28bde7
Source identifiers:
244061
Local pid:
pubs:244061
Language:
English

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