Two distinct receptors mediate nonopsonic phagocytosis of different strains of Pseudomonas aeruginosa.

Journal article

Complement receptor 3 (CR3) mediates both opsonic and nonopsonic phagocytosis of bacteria. Leukocyte adhesion deficiency (LAD) allows for the study of CR3-dependent phagocyte-bacterial ingestion, since LAD phagocytes do not express this receptor. Phagocytes from an infant with LAD were unable to ingest 50% of the Pseudomonas aeruginosa strains studied, which indicates a requirement for CR3. However, the remaining strains were phagocytosed in the absence of CR3, and ingestion was blocked by mo...

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Authors: Heale, J; Pollard, A; Stokes, R; Simpson, D; Tsang, A

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 183
• Issue: 8
• Pages: 1214-1220
• Publication date: 2001-04-01
• DOI: 10.1086/319685
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Cystic Fibrosis; Neutrophils; Flow Cytometry; Monocytes; Infant, Newborn; Antibodies, Monoclonal; Macrophages; Phagocytosis; Humans; Pseudomonas aeruginosa; Species Specificity; Adult; Leukocyte-Adhesion Deficiency Syndrome; Macrophage-1 Antigen; Antigens, CD14; Antigens, CD; Reference Values; Fetal Blood