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The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA.

Abstract:

The discovery and study of toxin-antitoxin (TA) systems helps us advance our understanding of the strategies prokaryotes employ to regulate cellular processes related to the general stress response, such as defense against phages, growth control, biofilm formation, persistence, and programmed cell death. Here we identify and characterize a TA system found in various bacteria, including the global pathogen Mycobacterium tuberculosis. The toxin of the system (DarT) is a domain of unknown functi...

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Publication status:
Published

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Department:
Oxford, MSD, Pathology Dunn School
Role:
Author

Contributors

281739/European Research Council More from this funder
Publisher:
Elsevier (Cell Press)
Journal:
Mol Cell
Issue:
6
Publication date:
2016-12-15
Acceptance date:
2016-11-04
DOI:
ISSN:
1097-2765 and 1097-4164
Pubs id:
pubs:666693
URN:
uri:dd3cf1aa-a6e9-4275-a9be-e40419a8c1d1
UUID:
uuid:dd3cf1aa-a6e9-4275-a9be-e40419a8c1d1
Local pid:
pubs:666693

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