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Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation.

Abstract:

Cep135/Bld10 is a conserved centriolar protein required for the formation of the central cartwheel, an early intermediate in centriole assembly. Surprisingly, Cep135/Bld10 is not essential for centriole duplication in Drosophila, suggesting either that Cep135/Bld10 is not essential for cartwheel formation, or that the cartwheel is not essential for centriole assembly in flies. Using electron tomography and super-resolution microscopy we show that centrioles can form a cartwheel in the absence...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.113506

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Journal:
Journal of cell science
Volume:
125
Issue:
Pt 23
Pages:
5881-5886
Publication date:
2012-12-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:dd24b4a2-4af9-4e6b-ae79-132d76a15a0e
Source identifiers:
352443
Local pid:
pubs:352443

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