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Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier.

Abstract:

Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death. What determines whether a DSB is repaired accurately or inaccurately is currently unclear. We provide evidence that suggests that perturbing replication by a non-programmed protein-DNA replication fork barrier results in the persistence of replication ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkr340

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Steinacher, R More by this author
Castagnetti, S More by this author
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Funding agency for:
Sofueva, S
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
39
Issue:
15
Pages:
6568-6584
Publication date:
2011-08-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:dd2353f5-9126-4485-8612-025c74314ea9
Source identifiers:
140627
Local pid:
pubs:140627

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