- Abstract:
-
The death-inducing signaling complex (DISC) formed by the death receptor Fas, the adaptor protein FADD and caspase-8 mediates the extrinsic apoptotic program. Mutations in Fas that disrupt the DISC cause autoimmune lymphoproliferative syndrome (ALPS). Here we show that the Fas-FADD death domain (DD) complex forms an asymmetric oligomeric structure composed of 5-7 Fas DD and 5 FADD DD, whose interfaces harbor ALPS-associated mutations. Structure-based mutations disrupt the Fas-FADD interaction...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nsmb.1920
-
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- Journal:
- Nature structural and molecular biology
- Volume:
- 17
- Issue:
- 11
- Pages:
- 1324-1329
- Publication date:
- 2010-11-05
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- URN:
-
uuid:dd1f102c-98fd-4985-be48-8f47b151fca4
- Source identifiers:
-
97315
- Local pid:
- pubs:97315
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations.
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