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Glyco-SeS: selenenylsulfide-mediated protein glycoconjugation--a new strategy in post-translational modification.

Abstract:
Site-selective glycosylation by Se-S-mediated ligation has led to the efficient formation of a wide variety of conjugates 1 without the need for a large excess of the carbohydrate reagent. By this convergent method it was possible to introduce a heptasaccharide glycan selectively, and to perform a multiple site-selective chemical glycosylation of protein. A chemically Cysglycosylated glycoprotein was elaborated enzymatically.
Publication status:
Published

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Publisher copy:
10.1002/anie.200352975

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Journal:
Angewandte Chemie (International ed. in English)
Volume:
43
Issue:
7
Pages:
828-833
Publication date:
2004-02-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:dd180df0-4765-41b1-bd19-1074077c2547
Source identifiers:
32620
Local pid:
pubs:32620

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