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In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during.

Abstract:

The aims of this study were twofold: (i) to determine quantitatively the contribution of glutamate/glutamine cycling to total astrocyte/neuron substrate trafficking for the replenishment of neurotransmitter glutamate; and (ii) to determine the relative contributions of anaplerotic flux and glutamate/glutamine cycling to total glutamine synthesis. In this work in vivo and in vitro (13)C NMR spectroscopy were used, with a [2-(13)C]glucose or [5-(13)C]glucose infusion, to determine the rates of ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Herskovits, AZ More by this author
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Journal:
Journal of neurochemistry
Volume:
76
Issue:
4
Pages:
975-989
Publication date:
2001-02-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:dd17da7f-3439-432e-ae6c-bbeedf3317c9
Source identifiers:
130846
Local pid:
pubs:130846

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