- Abstract:
-
The aims of this study were twofold: (i) to determine quantitatively the contribution of glutamate/glutamine cycling to total astrocyte/neuron substrate trafficking for the replenishment of neurotransmitter glutamate; and (ii) to determine the relative contributions of anaplerotic flux and glutamate/glutamine cycling to total glutamine synthesis. In this work in vivo and in vitro (13)C NMR spectroscopy were used, with a [2-(13)C]glucose or [5-(13)C]glucose infusion, to determine the rates of ...
Expand abstract - Publisher copy:
- 10.1046/j.1471-4159.2001.00074.x
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- Journal:
- Journal of neurochemistry
- Volume:
- 76
- Issue:
- 4
- Pages:
- 975-989
- Publication date:
- 2001-02-05
- DOI:
- EISSN:
-
1471-4159
- ISSN:
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0022-3042
- URN:
-
uuid:dd17da7f-3439-432e-ae6c-bbeedf3317c9
- Source identifiers:
-
130846
- Local pid:
- pubs:130846
- Copyright date:
- 2001
Journal article
In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during.
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