Amphiphilic porphyrins for second harmonic generation imaging.

Journal article

Amphiphilic donor-acceptor meso-ethynyl porphyrins with polar pyridinium electron-acceptor head groups and hydrophobic dialkyl-aniline electron donors have high molecular hyperpolarizabilities (as measured by hyper-Rayleigh scattering) and high affinities for biological membranes. When bound to water droplets in dodecane, or to the plasma membranes of living cells, they can be used for second harmonic generation (SHG) microscopy; an incident light of wavelength 840 nm generates a strong frequ...

Expand abstract

Authors: Reeve, J; Collins, H; De Mey, K; Kohl, M; Thorley, K

• Publication status: Published
• Journal: Journal of the American Chemical Society
• Volume: 131
• Issue: 8
• Pages: 2758-2759
• Publication date: 2009-03-01
• DOI: 10.1021/ja8061369
• EISSN: 1520-5126
• ISSN: 0002-7863
• Language: English
• Keywords: Microscopy, Fluorescence; Membrane Lipids; Humans; Copper; Cell Line, Tumor; Nickel; Porphyrins; Scattering, Radiation; Metalloporphyrins