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Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors.

Abstract:

Common vascular disease states including diabetes, hypertension and atherosclerosis are associated with endothelial dysfunction, characterised by reduced bioactivity of nitric oxide (NO). Loss of the vasculoprotective effects of NO contributes to disease progression, but the mechanisms underlying endothelial dysfunction remain unclear. Increased superoxide production in animal models of vascular disease contributes to reduced NO bioavailability, endothelial dysfunction and oxidative stress. I...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Volume:
53
Issue:
4 Pt 1
Pages:
515-524
Publication date:
2002-12-05
EISSN:
1899-1505
ISSN:
0867-5910
URN:
uuid:dd09e18f-f637-4aa1-abf2-80695e694a9e
Source identifiers:
105182
Local pid:
pubs:105182

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