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Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response

Abstract:

Peptidyl arginine deiminase (PAD) 4 is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and identity of reader domains specifically recognising citrulline modifications remain unclear. E2F transcription factors play an important role in regulating gene expression in diverse biological processes. Here, we show that E2F-1 is citrullinated by ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/sciadv.1501257

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More from this funder
Name:
European Union
Funding agency for:
Venables, P
Grant:
115142-2
097813/Z/11/Z
More from this funder
Name:
John Fell Fund
Funding agency for:
Kessler, B
Grant:
097813/Z/11/Z
133/075
More from this funder
Name:
Wellcome Trust
Funding agency for:
Picaud, S
Kessler, B
Grant:
097813/Z/11/Z
097813/Z/11/Z
095751/Z/11/Z
More from this funder
Name:
Cancer Research UK
Funding agency for:
Ghari, F
Kessler, B
Grant:
097813/Z/11/Z
C300/A13058
More from this funder
Name:
National Institutes of Health
Grant:
AM110394
Publisher:
American Association for the Advancement of Science
Journal:
Science Advances More from this journal
Volume:
2
Issue:
2
Article number:
e1501257
Publication date:
2016-02-05
Acceptance date:
2015-12-01
DOI:
ISSN:
2375-2548
Pubs id:
pubs:590888
UUID:
uuid:dd00ce0a-c025-4227-989d-5e337dd8637e
Local pid:
pubs:590888
Source identifiers:
590888
Deposit date:
2016-01-19

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