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Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22.

Abstract:

BACKGROUND and AIMS: The aim of this study was to evaluate the role of known colorectal adenoma and carcinoma susceptibility genes and to locate a novel susceptibility gene in an Ashkenazi family (SM1311) with dominantly inherited predisposition to colorectal adenomas and carcinomas. METHODS: Clinicopathologic and family history data were collected. Genetic linkage and mutational analyses were used to investigate the genetic basis of the family's disease. RESULTS: Affected members of SM1311 ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Frayling, I More by this author
Mangion, J More by this author
Barfoot, R More by this author
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Journal:
Gastroenterology
Volume:
116
Issue:
4
Pages:
789-795
Publication date:
1999-04-05
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
URN:
uuid:dcf4ff73-bfe7-4a51-9669-5e3f6b08d827
Source identifiers:
36930
Local pid:
pubs:36930

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