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Analysis of retinoblastoma age incidence data using a fully stochastic cancer model.

Abstract:

Retinoblastoma (RB) is an important ocular malignancy of childhood. It has been commonly accepted for some time that knockout of the two alleles of the RB1 gene is the principal molecular target associated with the occurrence of RB. In this article, we examine the validity of the two-hit theory for RB by comparing the fit of a stochastic model with two or more mutational stages. Unlike many such models, our model assumes a fully stochastic stem cell compartment, which is crucial to its behavi...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.26039

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Institution:
University of Oxford
Department:
Oxford, MSD, Population Health, NPEU
Role:
Author
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Journal:
International journal of cancer. Journal international du cancer
Volume:
130
Issue:
3
Pages:
631-640
Publication date:
2012-02-05
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:dcf0b094-767f-4fb0-a249-3cc6beaf993e
Source identifiers:
191275
Local pid:
pubs:191275

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