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Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons

Abstract:

Corticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output. Schemes of basal ganglia circuit dynamics generally consider striatal PV+ interneurons to be homogenous, despite considerable heterogeneity in both form and function. We demonstrate that the selective co-expression of another calcium-binding protein, secretagogin (Scgn), separates PV+ interneurons in rat and primate...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.7554/eLife.16088

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Department:
Oxford, MSD, Pharmacology, BNDU
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Department:
Oxford, MSD, Pharmacology, BNDU
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Department:
Oxford, MSD, Pharmacology, BNDU
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Department:
Oxford, MSD, Pharmacology, BNDU
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Department:
Oxford, MSD, Pharmacology, BNDU
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Grant:
109030/Z/15/Z; 101821
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Grant:
1531859; MC_UU_12020/5; MC_UU_12024/2; MC_UU_12024/1
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
5
Publication date:
2016-09-26
Acceptance date:
2016-08-25
DOI:
ISSN:
2050-084X
Pubs id:
pubs:642469
URN:
uri:dcef9f07-9f21-42e4-8500-afbf90b9cd9c
UUID:
uuid:dcef9f07-9f21-42e4-8500-afbf90b9cd9c
Local pid:
pubs:642469
Language:
English
Keywords:

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