Journal article icon

Journal article

The why and how of thymocyte negative selection.

Abstract:

The generation of T cell receptor (TCR) sequence diversity is the strength of adaptive immunity, yet is also the Achilles' heel. To purge highly self-reactive T cells from the immune system, generation of diversity has coevolved with a mechanism of negative selection. Recent studies have revealed new insights addressing the why and how of negative selection by examining situations in which negative selection has failed in human and animals models of autoimmunity. Both thymocyte extrinsic and ...

Expand abstract

Actions


Access Document


Publisher copy:
10.1016/j.coi.2006.01.001

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Makaroff, LE More by this author
Journal:
Current opinion in immunology
Volume:
18
Issue:
2
Pages:
175-183
Publication date:
2006-04-05
DOI:
EISSN:
1879-0372
ISSN:
0952-7915
URN:
uuid:dce6a7af-999e-4ec3-8699-0b920cc3b394
Source identifiers:
418830
Local pid:
pubs:418830

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP