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Using chemical genetics and ATP analogues to dissect protein kinase function

Abstract:

Protein kinases catalyze the transfer of the γ-phosphate of ATP to a protein substrate and thereby profoundly alter the properties of the phosphorylated protein. The identification of the substrates of protein kinases has proven to be a very difficult task because of the multitude of structurally related protein kinases present in cells, their apparent redundancy of function, and the lack of absolute specificity of small-molecule inhibitors. Here, we review approaches that utilize chemical ge...

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Publisher copy:
10.1021/cb700027u

Authors


Elphick, LM More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
ACS Chemical Biology
Volume:
2
Issue:
5
Pages:
299-314
Publication date:
2007-05-05
DOI:
ISSN:
1554-8929
URN:
uuid:dcd1e5db-4e8b-455b-9812-019a5da097a0
Source identifiers:
134234
Local pid:
pubs:134234
Language:
English

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