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Imaging-based screen identifies laminin 411 as a physiologically relevant niche factor with importance for i-Hep applications

Abstract:

Use of hepatocytes derived from induced pluripotent stem cells (i-Heps) is limited by their functional differences in comparison with primary cells. Extracellular niche factors likely play a critical role in bridging this gap. Using image-based characterization (high content analysis; HCA) of freshly isolated hepatocytes from 17 human donors, we devised and validated an algorithm (Hepatocyte Likeness Index; HLI) for comparing the hepatic properties of cells against a physiological gold standa...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.stemcr.2018.01.025

Authors


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Funding agency for:
Serra, MP
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Funding agency for:
Nakauchi, H
National Institute for Health Research More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Stem Cell Reports Journal website
Volume:
10
Issue:
3
Pages:
693-702
Publication date:
2018-03-01
Acceptance date:
2018-01-22
DOI:
ISSN:
2213-6711
Pubs id:
pubs:827345
URN:
uri:dcc147a4-5f35-4cc6-b4ad-bee79d318ee0
UUID:
uuid:dcc147a4-5f35-4cc6-b4ad-bee79d318ee0
Local pid:
pubs:827345
Keywords:

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