Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome.

Journal article

OBJECTIVE: Features of the metabolic syndrome such as central obesity with insulin resistance and dyslipidemia are typical signs of Cushing's syndrome and common side effects of prolonged glucocorticoid treatment. AMP-activated protein kinase (AMPK), a key regulatory enzyme of lipid and carbohydrate metabolism as well as appetite, is involved in the development of the deleterious metabolic effects of excess glucocorticoids, but no data are available in humans. In the current study, we demons...

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Authors: Kola, B; Christ-Crain, M; Lolli, F; Arnaldi, G; Giacchetti, G

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 93
• Issue: 12
• Pages: 4969-4973
• Publication date: 2008-12-01
• DOI: 10.1210/jc.2008-1297
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Phosphoenolpyruvate Carboxykinase (ATP); Lipid Metabolism; Middle Aged; Cyclic AMP-Dependent Protein Kinases; RNA, Messenger; Reverse Transcriptase Polymerase Chain Reaction; Humans; Adipose Tissue; Fatty Acid Synthetase Complex; Hydrocortisone; Female; Cushing Syndrome; Up-Regulation; Adrenal Gland Neoplasms; Obesity; Male