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Rapid turnover of effector-memory CD4(+) T cells in healthy humans.

Abstract:

Memory T cells can be divided into central-memory (T(CM)) and effector-memory (T(EM)) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar mechanisms. We used in vivo labeling with deuterated glucose to measure the turnover of CD4(+) T cells in healthy humans. The CD45R0(+)CCR7(-) T(EM) subpopulation was shown to have a rapid proliferation rate of 4.7% per day compared with 1.5% per day f...

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Publisher copy:
10.1084/jem.20040341

Authors


Macallan, DC More by this author
Wallace, D More by this author
De Lara, C More by this author
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Journal:
The Journal of experimental medicine
Volume:
200
Issue:
2
Pages:
255-260
Publication date:
2004-07-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:dcaf484e-f1c0-4297-b050-69bc901eae14
Source identifiers:
32775
Local pid:
pubs:32775

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