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The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow.

Abstract:

The I domain of lymphocyte function-associated antigen (LFA)-1 contains an intercellular adhesion molecule (ICAM)-1 and ICAM-3 binding site, but the relationship of this site to regulated adhesion is unknown. To study the adhesive properties of the LFA-1 I domain, we stably expressed a GPI-anchored form of this I domain (I-GPI) on the surface of baby hamster kidney cells. I-GPI cells bound soluble ICAM-1 (sICAM-1) with a low avidity and affinity. Flow cell experiments demonstrated a specific ...

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Publisher copy:
10.1084/jem.186.5.719

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
The Journal of experimental medicine
Volume:
186
Issue:
5
Pages:
719-730
Publication date:
1997-08-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:dc9f10ff-429b-4e85-9835-1a41fe094c43
Source identifiers:
482676
Local pid:
pubs:482676

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