- Abstract:
-
The I domain of lymphocyte function-associated antigen (LFA)-1 contains an intercellular adhesion molecule (ICAM)-1 and ICAM-3 binding site, but the relationship of this site to regulated adhesion is unknown. To study the adhesive properties of the LFA-1 I domain, we stably expressed a GPI-anchored form of this I domain (I-GPI) on the surface of baby hamster kidney cells. I-GPI cells bound soluble ICAM-1 (sICAM-1) with a low avidity and affinity. Flow cell experiments demonstrated a specific ...
Expand abstract - Publisher copy:
- 10.1084/jem.186.5.719
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 186
- Issue:
- 5
- Pages:
- 719-730
- Publication date:
- 1997-08-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:dc9f10ff-429b-4e85-9835-1a41fe094c43
- Source identifiers:
-
482676
- Local pid:
- pubs:482676
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow.
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