Journal article

Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy.

Abstract:: The New Delhi metallo-β-lactamase (NDM-1) is involved in the emerging antibiotic resistance problem. Development of metallo-β-lactamases (MBLs) inhibitors has proven challenging, due to their conformational flexibility. Here we report site-selective labeling of NDM-1 with 1,1,1-trifluoro-3-bromo acetone (BFA), and its use to study binding events and conformational changes upon ligand-metal binding using (19) F NMR spectroscopy. The results demonstrate different modes of binding of known NDM-1...
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Publication status:: Published

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APA Style

Rydzik, A., Brem, J., van Berkel, S., Pfeffer, I., Makena, A., Claridge, T., & Schofield, C. (2014). Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy. Angewandte Chemie (International Ed. in English), 53(12), 3129–3133.

MLA Style

Rydzik, A., et al. “Monitoring Conformational Changes in the NDM-1 Metallo-β-Lactamase by 19F NMR Spectroscopy.” Angewandte Chemie (International Ed. in English), vol. 53, no. 12, Wiley, 2014, pp. 3129–33.

Chicago Style

Rydzik, A, J Brem, S van Berkel, I Pfeffer, A Makena, T Claridge, and C Schofield. 2014. “Monitoring Conformational Changes in the NDM-1 Metallo-β-Lactamase by 19F NMR Spectroscopy.” Angewandte Chemie (International Ed. in English) 53 (12): 3129–33.
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Publisher copy:: 10.1002/anie.201310866

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+ Rydzik, A More by this author

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+ Brem, J More by this author

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+ van Berkel, S More by this author

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+ Pfeffer, I More by this author

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+ Makena, A More by this author

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Bibliographic Details

Publisher:: Wiley
Journal:: Angewandte Chemie (International ed. in English) More from this journal
Volume:: 53
Issue:: 12
Pages:: 3129-3133
Publication date:: 2014-03-01
DOI:: 10.1002/anie.201310866
EISSN:: 1521-3773
ISSN:: 1433-7851

Item Description

Language:: English
Keywords:: antibiotic resistance

NDM-1

metallo-β-lactamases

captopril

19F-NMR
Pubs id:: pubs:457802
UUID:: uuid:dc9a3d57-4967-4f40-a35c-0e3e79bae70a
Local pid:: pubs:457802
Source identifiers:: 457802
Deposit date:: 2014-05-12

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Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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