Evaluation of an enzyme immunoassay for plasma-free metanephrines in the diagnosis of catecholamine-secreting tumors.

Journal article

OBJECTIVE: To define the test characteristics of an enzyme immunoassay (EIA) for plasma-free metanephrines (metanephrine and normetanephrine) in the diagnosis of pheochromocytoma and paraganglioma. DESIGN: Prospective observational design from a single University Hospital. Twenty-four hour urine for catecholamines and plasma for free metanephrines were collected from patients with a clinical suspicion of pheochromocytoma or paraganglioma. Patient records were reviewed for clinical data, foll...

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Authors: Procopiou, M; Finney, H; Akker, SA; Chew, S; Drake, WM

• Publication status: Published
• Journal: European journal of endocrinology / European Federation of Endocrine Societies
• Volume: 161
• Issue: 1
• Pages: 131-140
• Publication date: 2009-07-01
• DOI: 10.1530/eje-09-0172
• EISSN: 1479-683X
• ISSN: 0804-4643
• Language: English
• Keywords: Immunoenzyme Techniques; Female; Humans; Catecholamines; Pheochromocytoma; Metanephrine; ROC Curve; Follow-Up Studies; Child; Cohort Studies; Normetanephrine; Sensitivity and Specificity; Middle Aged; Adult; Male; Adrenal Gland Neoplasms; Aged; Paraganglioma; Adolescent; Aged, 80 and over