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MLL associates specifically with a subset of transcriptionally active target genes.

Abstract:

MLL (mixed-lineage leukemia) is a histone H3 Lys-4 specific methyltransferase that is a positive regulator of Hox expression. MLL rearrangements and amplification are common in acute lymphoid and myeloid leukemias and myelodysplastic disorders and are associated with abnormal up-regulation of Hox gene expression. Although MLL is expressed throughout hematopoiesis, Hox gene expression is sharply down-regulated during differentiation, suggesting that either the activity of MLL or its associatio...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0503630102

Authors


Martin, ME More by this author
Roeder, RG More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
102
Issue:
41
Pages:
14765-14770
Publication date:
2005-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:dc8ede6c-8d28-4175-8555-ebde9d08d8df
Source identifiers:
331904
Local pid:
pubs:331904

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