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Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro

Abstract:

Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12-42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about...

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Publisher copy:
10.1017/S0031182004005025

Authors


Ferguson, DJP More by this author
Schiflett, A More by this author
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Journal:
Parasitology
Volume:
128
Issue:
6
Pages:
577-584
Publication date:
2004-06-05
DOI:
EISSN:
1469-8161
ISSN:
0031-1820
URN:
uuid:dc896be9-97c0-4742-b698-06b4d6098248
Source identifiers:
246470
Local pid:
pubs:246470
Language:
English
Keywords:

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