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Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin.

Abstract:

The glycoprotein IgM is the major antibody produced in the primary immune response to antigens, circulating in the serum both as a pentamer and a hexamer. Pentameric IgM has a single J chain, which is absent in the hexamer. The mu (heavy) chain of IgM has five N-linked glycosylation sites. Asn-171, Asn-332, and Asn-395 are occupied by complex glycans, whereas Asn-402 and Asn-563 are occupied by oligomannose glycans. The glycosylation of human polyclonal IgM from serum has been analyzed. IgM w...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m504528200

Authors


Arnold, JN More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Radcliffe, CM More by this author
Harvey, DJ More by this author
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Journal:
The Journal of biological chemistry
Volume:
280
Issue:
32
Pages:
29080-29087
Publication date:
2005-08-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:dc7e5467-12c1-4c3e-bab6-2d96c94996ee
Source identifiers:
100144
Local pid:
pubs:100144

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