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SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.

Abstract:

Regulators of mitosis have been successfully targeted to enhance response to taxane chemotherapy. Here, we show that the salt inducible kinase 2 (SIK2) localizes at the centrosome, plays a key role in the initiation of mitosis, and regulates the localization of the centrosome linker protein, C-Nap1, through S2392 phosphorylation. Interference with the known SIK2 inhibitor PKA induced SIK2-dependent centrosome splitting in interphase while SIK2 depletion blocked centrosome separation in mitosi...

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Publication status:
Published

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Publisher copy:
10.1016/j.ccr.2010.06.018

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Journal:
Cancer cell
Volume:
18
Issue:
2
Pages:
109-121
Publication date:
2010-08-05
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:dc7cd1a4-f389-4870-b921-4c723d5915f5
Source identifiers:
314889
Local pid:
pubs:314889

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