Effect of testosterone on post-myocardial infarction remodeling and function.

Journal article

BACKGROUND: Men and women are differently affected by coronary artery disease, suggesting an important role of sex steroids. Moreover, testosterone (T) treatment is increasingly used in elderly males. Therefore, we examined effects of chronic anabolic T administration on left ventricular (LV) remodeling after myocardial infarction (MI). METHODS: Adult male rats were treated with intramuscular placebo, testosterone undecanoate (T), or were orchiectomized. After 2 weeks, animals underwent sham...

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Authors: Nahrendorf, M; Frantz, S; Hu, K; von zur Mühlen, C; Tomaszewski, M

• Publication status: Published
• Journal: Cardiovascular research
• Volume: 57
• Issue: 2
• Pages: 370-378
• Publication date: 2003-02-01
• DOI: 10.1016/s0008-6363(02)00701-0
• EISSN: 1755-3245
• ISSN: 0008-6363
• Language: English
• Keywords: Rats, Wistar; Animals; Rats; Myocardial Infarction; Insulin-Like Growth Factor I; Magnetic Resonance Imaging, Cine; Hypertrophy, Left Ventricular; Gene Expression Regulation; Testosterone; Male; RNA, Messenger; Hemodynamics; Ventricular Remodeling