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Journal article

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis.

Abstract:

Immune responses to persistent viral infections and cancer often fail because of intense regulation of antigen-specific T cells-a process referred to as immune exhaustion. The mechanisms that underlie the induction of exhaustion are not completely understood. To gain novel insights into this process, we simultaneously examined the dynamics of virus-specific CD8(+) and CD4(+) T cells in the living spleen by two-photon microscopy (TPM) during the establishment of an acute or persistent viral in...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20121416

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Journal:
The Journal of experimental medicine
Volume:
210
Issue:
4
Pages:
757-774
Publication date:
2013-04-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:dc7361c4-ea0a-4a14-bd20-ef9cd4ca4e3b
Source identifiers:
404922
Local pid:
pubs:404922

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