- Abstract:
-
Immune responses to persistent viral infections and cancer often fail because of intense regulation of antigen-specific T cells-a process referred to as immune exhaustion. The mechanisms that underlie the induction of exhaustion are not completely understood. To gain novel insights into this process, we simultaneously examined the dynamics of virus-specific CD8(+) and CD4(+) T cells in the living spleen by two-photon microscopy (TPM) during the establishment of an acute or persistent viral in...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.20121416
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 210
- Issue:
- 4
- Pages:
- 757-774
- Publication date:
- 2013-04-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:dc7361c4-ea0a-4a14-bd20-ef9cd4ca4e3b
- Source identifiers:
-
404922
- Local pid:
- pubs:404922
- Copyright date:
- 2013
Journal article
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis.
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