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Journal article

Binding of Plasmodium falciparum merozoite surface proteins DBLMSP and DBLMSP2 to human immunoglobulin M Is conserved among broadly diverged sequence variants

Abstract:

Diversity at pathogen genetic loci can be driven by host adaptive immune selection pressure and may reveal proteins important for parasite biology. Population-based genome sequencing of Plasmodium falciparum, the parasite responsible for the most severe form of malaria, has highlighted two related polymorphic genes called dblmsp and dblmsp2, which encode Duffy binding-like (DBL) domain-containing proteins located on the merozoite surface but whose function remains unknown. Using recombinant p...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1074/jbc.m116.722074

Authors


Crosnier, C More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
ORCID:
0000-0001-8466-7547
Knuepfer, E More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
MSD Doctoral Training Centre
Perrin, AJ More by this author
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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
291
Issue:
27
Pages:
14285-14299
Publication date:
2016-05-05
Acceptance date:
2016-05-09
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pubs id:
pubs:630013
URN:
uri:dc687b10-490f-4ff6-be4c-0005bf79275b
UUID:
uuid:dc687b10-490f-4ff6-be4c-0005bf79275b
Local pid:
pubs:630013

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