High-dose naloxone modifies cardiovascular and neuroendocrine function in ambulant subjects.

Journal article

To determine the role of the opioids in the control of the cardiovascular system in awake ambulatory subjects, eight healthy men were infused with a high dose of naloxone (10 mg bolus plus 7 mg/hr), or saline placebo, for 12 hr. Ambulatory monitoring of blood pressure and heart rate every 10 min indicated no differences between trials for blood pressure (p greater than 0.80), but a significant difference for the maximal heart rate response during stair climbing or 1 km walks (p less than 0.02...

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Authors: McMurray, R; Newbould, E; Bouloux, P; Besser, G; Grossman, A

• Publication status: Published
• Journal: Psychoneuroendocrinology
• Volume: 16
• Issue: 5
• Pages: 447-455
• Publication date: 1991-01-01
• DOI: 10.1016/0306-4530(91)90010-q
• EISSN: 1873-3360
• ISSN: 0306-4530
• Language: English
• Keywords: Receptors, Opioid; Arousal; Humans; Heart Rate; Luteinizing Hormone; Male; Circadian Rhythm; Naloxone; Epinephrine; Follicle Stimulating Hormone; Blood Pressure; Adult; Hydrocortisone; Dose-Response Relationship, Drug; Dopamine