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Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway.

Abstract:

Over-expression of truncated epidermal growth factor receptor (EGFR) occurs in a variety of malignancies including glioblastoma multiforme, breast and lung cancer. The truncation deletes an extracellular domain and results in constitutive activation of the receptor. NIH3T3 cells were transfected with full length or truncated human EGFR and differences in growth rates in vivo and in vitro analysed. A growth advantage was seen for cells expressing mutant receptor compared to full length EGFR in...

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Publication status:
Published

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Publisher copy:
10.1054/bjoc.2001.1805

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Gullick, WJ More by this author
Harris, AL More by this author
Journal:
British journal of cancer
Volume:
84
Issue:
10
Pages:
1322-1329
Publication date:
2001-05-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:dc571dd9-c481-4189-b1f3-63db230688de
Source identifiers:
106553
Local pid:
pubs:106553

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