The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation.

Journal article

BACKGROUND: Activated microglia are a feature of the host response to neurodegeneration in Parkinson's disease (PD) and are thought to contribute to disease progression. Recent evidence suggests that extracellular α-synuclein (eSNCA) may play an important role in the pathogenesis of PD and that this may be mediated by a microglial response. METHODS: We wished to discover whether the host response to eSNCA would be sufficient to induce significant cytokine production. In vitro cultured BV-2 m...

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Authors: Couch, Y; Alvarez-Erviti, L; Sibson, N; Wood, M; Anthony, D

• Publication status: Published
• Journal: Journal of neuroinflammation
• Volume: 8
• Issue: 1
• Pages: 166
• Publication date: 2011-01-01
• DOI: 10.1186/1742-2094-8-166
• EISSN: 1742-2094
• ISSN: 1742-2094
• Language: English
• Keywords: Microglia; alpha-Synuclein; Serum Albumin; Tumor Necrosis Factor-alpha; Mice; Interleukin-1beta; Animals; Parkinson Disease; Cell Death; Inflammation; Cytokines; Substantia Nigra; Lipopolysaccharides; Amyloid beta-Peptides; Cell Line; Female; Transcription Factor RelA