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The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation.

Abstract:

BACKGROUND: Activated microglia are a feature of the host response to neurodegeneration in Parkinson's disease (PD) and are thought to contribute to disease progression. Recent evidence suggests that extracellular α-synuclein (eSNCA) may play an important role in the pathogenesis of PD and that this may be mediated by a microglial response. METHODS: We wished to discover whether the host response to eSNCA would be sufficient to induce significant cytokine production. In vitro cultured BV-2 m...

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Publication status:
Published

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Publisher copy:
10.1186/1742-2094-8-166

Authors


Alvarez-Erviti, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Journal of neuroinflammation
Volume:
8
Issue:
1
Pages:
166
Publication date:
2011
DOI:
EISSN:
1742-2094
ISSN:
1742-2094
URN:
uuid:dc544d5b-413a-429b-8c4d-714338b8377b
Source identifiers:
216075
Local pid:
pubs:216075

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