Fatty acid and triacylglycerol utilisation by perfused rat spleen: differential metabolic fate and the effect of endotoxin.
BACKGROUND/AIMS: The spleen uses significant amounts of non-esterified fatty acid (NEFA) and chylomicron (CM)-derived triacylglycerol (TAG); however, its utilisation of very-low-density lipoprotein triacylglycerol (VLDL-TAG), and the effect of endotoxin on lipid assimilation and fate are unknown. This study aims to define spleen utilisation of esterified and non-esterified fatty acid in quiescent and endotoxin-stimulated states. METHODS: Rat spleens were perfused for 2h with glucose (11mM) an...Expand abstract
- Publisher copy:
- Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
- Publication date:
- Source identifiers:
- Local pid:
- Copyright date: