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Fatty acid and triacylglycerol utilisation by perfused rat spleen: differential metabolic fate and the effect of endotoxin.

Abstract:

BACKGROUND/AIMS: The spleen uses significant amounts of non-esterified fatty acid (NEFA) and chylomicron (CM)-derived triacylglycerol (TAG); however, its utilisation of very-low-density lipoprotein triacylglycerol (VLDL-TAG), and the effect of endotoxin on lipid assimilation and fate are unknown. This study aims to define spleen utilisation of esterified and non-esterified fatty acid in quiescent and endotoxin-stimulated states. METHODS: Rat spleens were perfused for 2h with glucose (11mM) an...

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Publisher copy:
10.1159/000063791

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Journal:
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Volume:
12
Issue:
2-3
Pages:
143-152
Publication date:
2002
DOI:
EISSN:
1421-9778
ISSN:
1015-8987
URN:
uuid:dc518e00-c7e5-4f26-b632-d31dcf1b089a
Source identifiers:
238059
Local pid:
pubs:238059

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