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Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy

Abstract:

Background and purpose: For patients diagnosed with advanced renal cell carcinoma (RCC), there are few therapeutic options. Radiation therapy is predominantly used to treat metastasis and has not proven effective in the adjuvant setting for renal cancer. Furthermore, RCC is resistant to standard cytotoxic chemotherapies. Targeted anti-angiogenics are the standard of care for RCC but are not curative. Newer agents, such as mTOR inhibitors and others that induce autophagy, have shown great prom...

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Authors


Anbalagan, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Ferguson, DJP More by this author
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Journal:
Radiotherapy and Oncology
Volume:
103
Issue:
3
Pages:
388-393
Publication date:
2012-06-05
DOI:
EISSN:
1879-0887
ISSN:
0167-8140
URN:
uuid:dc39d200-9e84-4de1-88fe-79054da4c6fd
Source identifiers:
340229
Local pid:
pubs:340229
Language:
English
Keywords:

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